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'''Zolpidem''', sold as the brand name '''Ambien''' among others,Drugs.com [http://www.drugs.com/international/zolpidem.html International listings for zolpidem] Page accessed Feb 23, 2016 is a sedative primarily used for the treatment of insomnia|trouble sleeping. It usually works within 15 minutes, and has a short Elimination half-life|half-life of two to three hours. Zolpidem has not adequately demonstrated effectiveness in maintaining sleep, unless delivered in a controlled-release (CR) form. However, it is effective in initiating sleep. Its hypnotic effects are similar to those of the benzodiazepine class of drugs. In 2013, the Food and Drug Administration required manufacturers to decrease the recommended dose for women by half, after studies showed that the medicines can leave people drowsy in the morning and at risk for motor vehicle collisions. The FDA recommended that manufacturers extend the new dosage cuts to men as well, who...
Verifiedrevid418554530
TradenameAmbien, others
Legal statusRx-only
Dependency liabilityHigh
Routes of administrationBy mouth (tablet), Sublingual administration|sublingual, oromucosal (spray), Rectal administration|rectal
Bioavailability70% (by mouth)
Protein bound92%
MetabolismLiver through CYP3A4
ExcretionKidney (56%)
Feces|fecal (34%)
Molecular weight307.395 g/mol
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